益母草治疗心肌缺血或再灌注损伤及其机制研究

Curative Effects of Herba Leonuri on Myocardial Ischemia or Reperfusion Injury and It′s Mechanism

目的 :观察益母草对心肌缺血或再灌注损伤的疗效并探讨其机制。方法 :30只新西兰白兔等分为正常组、缺血再灌注对照组、益母草治疗组。治疗组兔、5 2例冠心病及 30例无症状性心肌缺血患者 ,用益母草注射液静滴治疗。 5 4例心肌缺血患者用益母草片治疗。结果 :治疗组兔缺血及再灌注的心功能 ,心肌酶释出明显改善 ;血浆及心肌组织的丙二醛含量降低 ,血浆及心肌组织SOD、全血GSH Px、心肌组织ATP酶活性高于对照组 ,心肌组织Ca2 +含量低于对照组。心肌缺血患者用益母草治疗后 ,症状、体征、心电图、血脂、微循环及血液流变性明显改善。结论 :益母草对心肌缺血及再灌注损伤有明显疗效。其机制与减少氧自由基及细胞内钙超载对心肌细胞损伤、改善缺血区心肌微循环及血液流变性有关。

Objective: To investigate the curative effects of herba leonuri on myocardial ischemia or reperfusion injury in rabbits and patients and its mechanism.Method: 30 New Zealand rabbits were randomly divided into the normaol control group(NCG),the ischemia-reperfusion control groups(IRG) and the therapeutic group with Injectio herba leonuri(HLG).50 cases with myocardial ischemia(MI) and 30 cases with silent myocardial ischemia(SMI) were treated with injectio leonuri.54 cases with myocardial ischemia were treated with tablet herba leonuri.Results: The cardial functions of HLG were improved.The leakage or myocardial eniymes(CK,AST,LDH-L,αHBDH) from cardiac muscle cells were minimized.The levels of MDA in plasma and myocardiul tissue were obviously higher than those of IRG(P<0.05)?The activitees of Ca 2+ ATPase,Na +-K +-ATPase,Mg 2+ ATPase,in the ischemia-reperfused region of myocardial tissue in LHG were higher than those in IRG.The content of Ca 2+ in the ischemia-reperfused region of myocardial tissue of LHG were lower than that of IRG.After HL therapy,the symptoms,signs,ECG lipidemia,indexes of hemorheology and microcirculation in the MI and SMI patients were obviously improved.Conclusion: The results showed that herba leonuri was significantly effective in curing myocardial ischemia and referfusion injury.It′s mechanism may be related to allaying myocardial injury induced by oxygen radicals,lessing the overload of Ca 2+ ,improving hemorheology and microcirculation in the myocardial ischemic region.