摘要
目的 :探讨粘附分子在脑梗塞不同时期含量变化作用机理以及临床意义。方法 :利用酶联免疫吸附法 (ELISA)分别监测脑梗塞急性期、恢复期可溶性细胞间粘附分子 1(sICAM 1)、E 选择素 (sE se lectin)血清含量。结果 :脑梗塞急性期sICAM 1、sE selectin含量明显升高 ,与恢复期及对照组比较有显著差异 (P <0 .0 5 ) ,sICAM 1、、sE selectin二者含量显著相关 (P <0 .0 5 )。结论 :粘附分子sICAM 1、、sE selectin共同介导了白细胞的滚动浸润 ,参与了脑梗塞急性期的炎症损伤。
Objective: To explore the mechanism and clinical measuring of sICAM-1 and sE-selectin in patients with cerebral infarction.Method: The serum level of sICAM-1,sE-selectin were measured on 36 cases of acute cerebral infarction(CI),19 cases of remission stage of CI,20 cases of normal groups by ELISA method.Results: The results showed that serum sICAM-1,sE-selectin concentrations were significantly higher in acute cerebral infarction than in controls and remission stage of CI(P<0.05),sICAM-1,sE-selectin had significant correlation in acute stage of CI(rs=0.280 6,P<0.05).Conclusion: This suggests that soluble adhesion molecules sICAM-1,sE-selectin both mediate leukocyte adhesion,migration and relate with cerebral ischemic inflammatory injury.
出处
《微循环学杂志》
2001年第4期30-31,共2页
Chinese Journal of Microcirculation
