遗传性视网膜劈裂症的多焦视网膜电图改变

The multifocal electroretinogram in inherited retinoschisis

目的 应用多焦视网膜电图对正常对照眼和视网膜劈裂眼进行检测并比较两者之间的差异。 方法 用 VERIS Science TM 4.0视诱发反应图像系统对 19例 (2 1只眼 )正常对照者和 8例 (15只眼 )视网膜劈裂者进行检测 ,并用全视野视网膜电图 (electroretinogram,ERG)对其中 3例 (6只眼 )视网膜劈裂者进行检测。 结果 正常对照组和视网膜劈裂组 6个环形视网膜区域平均反应密度值或潜伏期比较均显示差异有非常显著性的意义 ,视网膜劈裂患者多焦 ERG三维图皆表现为多处局部性振幅降低 ,中央高峰反应消失或降低 ,其 6个环形视网膜区域反应密度值的 P1 / N1 波比值不同于全视野 ERG的 b/ a波比值。 结论 多焦 ERG和全视野 ERG对视网膜劈裂的诊断各有其优点。

Objective To measure and compare the difference between the normal control and retinoschisis with multifocal electroretinography. Methods Nineteen cases (21 eyes) of normal control and 8 cases (15 eyes) of inherited retinoschisis were measured with VERIS Science TM 4.0. Three cases (6 eyes) of inherited retinoschisis were tested with Ganzfeld ERG. Results There was statistically significant difference of average response density and latencies in all 6 ring retinal regions between the normal control and retinoschisis. The topography of multifocal ERG showed that multifocal amplitude decreased with disappearing or decreasing of central peak amplitude in patients with retinoschisis. The P 1/N 1 ratio of the multifocal ERG average response densities in 6 ring retinal regions was different from the b/a ratio of the Ganzfeld ERG. Conclusion Each of the multifocal ERG and Ganzfeld ERG has its advantage in the diagnosis of the retinoschisis.