多焦视网膜电图各项参数的变异性

The variability of parameters of multi-focal electroretinogram

目的 对正常眼的多焦视网膜电图 (multi- focal electroretinogram,m ERG)测试 ,比较 a、b波振幅、a、b波潜伏期 4个参数变异性的大小 ,以便找出相对稳定的参数。 方法 受试者 46例 (6 0只眼 )年龄在 14～ 70岁之间 ,按年龄共分 3组 ,每组 2 0只眼。用 Rodenstock的 RETIscan3.12系统进行 m ERG测定。 6 1个 6边形从中央到周边共分为 5个环。测定 2 4°视野范围的一阶反应 (first- order kernel)。 结果 m ERG各项参数变异较大。其中 b波潜伏期变异最小 ,变异系数 4.5 2 %～ 15 .6 2 % ;其次是 a波潜伏期变异系数 10 .2 9%～ 48.6 7% ;b波振幅变异较大 ,变异系数 2 5 .92 %～ 76 .11% ;a波振幅变异最大 ,变异系数 43.82 %～ 88.2 3%。a、b波的振幅密度随离心距离的增加而降低。 3个年龄组 m ERG的环 1b波振幅变异最小。 结论 3个年龄组均表明潜伏期变异比振幅小 ,b波变异比 a波小。a、b波的振幅密度随离心距离的增加而降低。

Objective To evaluate the variability of four parameters of multi-focal electroretinogram (mERG) a-wave amplitude, b-wave amplitude, a-wave latent period, b-wave latent period. Methods Sixty normal eyes of 46 volunteers were divided into 3 groups of different ages. RETIscan 3 12 system was used to carry out mERG examination. The stimulus matrix of 61 hexagonal elements spanning the central 24°of the visual field. These hexons were scaled with eccentricity and divided into 5 rings. First-order kernel was selected. Results The variability of four parameters of mERG was great. The variability of b-wave latent period was the smallest, its coefficient of variatian was 4.52%～15.62%;that of a-wave latent period held the second place:10.29%~48.67%;that of b-wave amplitude was greater:25.92%~76.11%;that of a-wave amplitude was the greatest:43.82%~88.23%. The results of three groups showed that b-wave amplitude of ring 1 had the smallest variability. Conclusions The variability of latent period is smaller than that of amplitude; the variability of b-wave was smaller than that of a-wave. The longer the centrifugal distance, the lower the amplitude density of a-wave and b-wave. Physiological and anatomical factors might be important for the variability of parameters of multi-focal electroretinogram.