抗肝吸虫药三氯苯达唑的合成

Synthesis of Triclabendazole

从 1,2 ,4-三氯苯出发 ,经硝化、氨化、醚化、还原、环合和甲基化等 6步反应合成三氯苯达唑。经工艺改进 ,总收率达 2 0 %

Triclabendazole was prepared from 1,2,4 trichlorobenzene via six step reaction, such as nitration, aminolysis, condensation, reduction, cyclization and methylation. Some reaction conditions had been improved and the total yield was up to 20%.