载脂蛋白B基因多态性与心肌梗死的关系

The relation between polymorphisms of apliporprotein B gene and myocardial infarction.

目的 研究载脂蛋白B(apoB)基因多态性与心肌梗死发病的关系。 方法 用聚合酶链反应 (PCR)法对 6 5例心肌梗死 (MI)患者和 6 0例正常人apoB基因XbaI和MspI两个酶切位点上限制性片段长度多态性(RFLPs)进行检测。结果 MI组Xbal酶切位点上X +等位基因频率显著高于对照组 ,分别为 0 0 92和 0 0 2 5(P <0 0 5 )。MspI酶切点位上M -等位基因相对频率在MI组和对照组之间无明显差异。

Objective To study the relationship between the apolipoprotein B(apo B) gene polymorphism and mycoardial infarction.Methods Two polymorphic sites of the apo B gene,Xba1 and Msp1 were examined by PCR in a sample of 65 patients with myocardial infarction(MI) and 60 healthy individuals selected from a population of the chinese Han nationality.Results The frequency of X+allele(presence of Xba1 cutting site)in MI cases was significantly higher than that in controls(P<0 05),respectively 0 092 and 0 025.The frequency of M-allele(presence of Msp1 cutting site) was no difference between MI cases and controls in statistics.Conclusions Genetic variation at Xba1 site of apo B may be independent prediction in the myocardial infarction.