D-二聚体在冠心病中的应用价值

The clinical application of plasm D-dimer in the patients with coronary heart disease

目的 评价血浆D -二聚体 (D -dimer,DD)在诊断冠心病及急性心肌梗死 (AMI)溶栓治疗疗效的临床应用价值。方法 采用酶联免疫吸附试验 (ELISA)检测心绞痛、陈旧性心肌梗死 (OMI)及急性心肌梗死 (AMI)患者血浆DD含量 (AMI患者发病后进行连续测定 ) ,并比较其结果。结果 2 0例健康对照组DD为 0 .40±0 .31mg/L ,18例心绞痛患者DD为 0 .5 6± 0 .35mg/L ,16例OMI患者DD为 0 .6 1± 0 .47mg/L ,8例未接受溶栓的AMI患者DD为 1.0 1± 0 .5 2mg/L。 15例接受溶栓治疗的AMI患者DD为 2 .92± 1.0 3mg/L(其中 12例溶栓有效者为 3.0 5± 1.0 5mg/L)。 结论 血浆DD测定不仅可作为观察心肌梗死病情的指标 。

Objectives To evaluate the clinical application of plasm D-dimer in the diagnosis of coronary heart disease and the effects of unthromboembolism treatment on the patients with acute myocardial infarction.Methods ELISA was used in the detection of plasma D-dimer contents in the patients with angina pectoris,old myocardial infarction(OMI)and acute myocardial infarction(AMI)and compare their results.Results The 20 healthy contrast group's D-dimer contents were 0.40±0.31mg/L,the 18 patients' with angina pectosis were 0.56±0.35mg/L.the 16 patients' with OMI were 0.61±0.47mg/L,and the 8 patients' with AMI without accepting the unthromboembolism were 1.01±0.52mg/L.The 15 patients' with AMI who accepted thrombsis treatment were 2.92±1.03mg/L.Conclusions The detection of plasma D-dimer can become the index that object the myocardial infarction and there's an important significance for detection the action of treatment with accepting the unthromboembolism.