妊高征患者血浆一氧化氮与内皮素及全血血小板聚集性变化的研究

Studies on the Level of Plasma Nitric Oxide,Endothelin-1 and Platelet Aggregation in Patients with Pregnancy Induced Hypertension

目的 探讨妊高征患者全血血小板聚集性、内皮素 (ET - 1)水平的变化以及与一氧化氮 (NO)水平变化的相关性。方法 分别采用电阻法、放射免疫法及硝酸还原酶法测定 5 9例妊高征患者、2 0例正常晚孕妇女的全血血小板聚集 (PAg)性、血浆ET - 1与NO水平。结果 与正常晚孕组比较 ,重度妊高征组血浆NO水平显著下降 (P <0 .0 1) ,而妊高征各组血浆ET - 1水平升高 (P <0 .0 1) ,同时全血PAg性增强 (P <0 .0 5 ,P <0 .0 1)且ET - 1和PAg二者与NO水平呈显著负相关 (P <0 .0 1)。结论 ET - 1及全血PAg性与妊高征的病情发展有关 ,NO与ET -

Objective To study the changes of platelet aggregation(PAg) and Endothelin-1(ET-1) and nitric oxide(NO).Methods The PAg,ET-1 and NO levels in 59 cases of PIH,20 normal term pregnant women were observed.Results Compared with normal term pregnant women,plasma NO levels in PIH group were lower,especially in moderate and severe PIH group(P<0.01).ET-1 level and platelet aggregation were significantly higher in three groups of PIH than those of normal term pregnant women(P<0.05),there was a significant negative correlation between ET-1 level,platelet aggregation and NO level(P<0.01).Conclusion The results suggest that the ET and platelet aggregation are associated with pathogenesis of PIH,NO may be one of the antagonist of ET-1 in the pathogenesis of PIH.