外伤后持续植物状态病人血NO水平及意义

The Level of NO in Blood of Patients With Persistent Vegetative State Resulted From Trauma

目的 探讨严重颅脑外伤后持续性植物状态病人外周血NO水平与病人免疫力降低的关系。方法 应用硝酸还原酶比色法及放免法检测 12例严重颅脑外伤后持续性植物状态病人外周血糖皮质激素和NO水平 ,观察该疾病患者外周血单核细胞对白色念珠菌的吞噬及杀灭作用。结果 严重颅脑外伤后持续性植物状态病人外周血NO水平明显降低 ,糖皮质激素水平基本在正常范围内。

Objective To investigate the relationship between the impairment of immunity and the level of NO in peripheral blood in patients with persistent vegetative state(PVS) resulting from severe brain trauma.Methods The levels of the cortisol and NO in peripheral blood of 12 PVS patients and the control group were tested respectively by radioimmunoassay and nitratase reducing colorimetic method.The phagocytosis and killing of Candida albicans by monocytes were observed.Results The NO content in peripheral blood of PVS group was dropped obviously,but the cortisol level was basically in normal range.Conclusion The suppression of immunity of PVS patients resulted from severe head trauma is related to the decreasing of the NO content in peripheral blood.