1992～2000年血友病甲患者HBsAg、抗-HIV和梅毒阳性率调查分析

Snrvey and Analysis of Positive Rate of HBsAg, HIV and Syphilis in Patients with Hemophilia A during 1992-2000

目的 了解血友病甲患者乙型肝炎病毒（HBV）、艾滋病病毒（HIV）及梅毒的感染情况。方法 对1992～2000年山东省血液中心血友病研究室确诊和治疗的162例血友病甲患者进行了HBsAg、丙氨酸氨基转移酶（ALT）、抗-HIV和梅毒抗体血清检测,并随机选择1000例无偿献血者作为正常对照。结果162例血友病甲患者HBsAg和ALT阳性率分别为4.32％（7/162）和8.64 ％（14/162）,无偿献血者HBsAg和ALT阳性率分别为10.00％（100/1000）和2.00％（20/1000）;血友病甲患者和无偿献血者抗-HIV和梅毒抗体阳性率均为零。结论 血友病甲患者ALT阳性率高于无偿献血者（x2=21.65,P<0.05）,HBsAg阳性率低于无偿献血者（x2=6.72,P<0.05）,血友病甲患者和无偿献血者均无 HIV和梅毒流行。

Objective To understand the infection with hepatitis B virus(HBV), Human immunodeficiency virus(HIV) and syphilis in patients with hemophilia A. Methods HBsAg, ALT, anti-HIV and syphilis in patients hemophilia A during 1992-2000 were analyzed.Randomitzd samples of 1 000 voluntary donors were taken as control. Results In 162 patients with hemophilia A investigated, the positive rates of HBsAg and ALT were 4.32% and 8.64%, respectively.The positive rates of HBsAg and ALT in 1 000 voluntary donors were 10.00% and 2.00%, respectively.The infection of HIV and syphilis were not found in 162 patients with hemophilia A and 1 000 donors. Conclusion The results revealed that the positive rate of ALT in patients with hemophilia A was higher than that in voluntary donors, but the positive rate of HBsAg in such patients was lower than that in voluntary donors. There was neither HIV nor syphilis transmission in patientss with hemophilia A or voluntary donors.