原发性骨质疏松症患者骨代谢指标初步研究

The primary investigation on the indexes of bone metabolic in primary osteoporosis

目的 探讨原发性骨质疏松症骨吸收和骨形成的生化指标与骨密度关系。方法 分别测定绝经后女性疏松组 (n =2 0 )、绝经后女性正常组 (n =2 0 ) ;中年男性疏松组 (n =2 0 )、中年男性正常组 (n =2 0 )、青年男性正常组 (n =1 5 )外周血钙 (Ca2 +)、磷 (P3- )、血清Ⅰ型前胶原羧基末端前肽 (PICP)、Ⅰ型胶原交联羧基末端肽 (ICTP) ,比较各组差异。结果 各组血清钙、磷测量值无显著性差异 ,绝经后女性疏松组与正常组相比PICP、ICTP值均升高 ,中年男性疏松组与正常组相比PICP值降低、ICTP值升高 ;与青年男性正常组相比 ,PICP值降低、ICTP值无显著性差异。结论 绝经后骨质疏松骨吸收和骨形成均升高 ,但骨吸收大于骨形成 ;中年男性骨质疏松随增龄骨形成生化指标降低 ,骨吸收生化指标增高 ,PICP和ICTP的联合检测有助于骨质疏松的早期诊断。

Objective The relationship was investigated between BMD(bone mineral density)and biochemical markers of bone resorption and formation in primary osteoporosis.Methods Serum Ca 2+ ,P 3- ,PICP and ICTP were determined in postmenopausal osteoporosis group, normal postmenopausal female group;middle-aged male osteoporosis group,normal middle-aged male group,normal young male group,results were compared among groups.Results There was no significant difference on the level of Ca 2+ ,P 3- among groups.Both ICTP and PICP increased in postmenopausal osteoporosis group compared with that of control group,PICP decreased while ICTP increased in middle-aged male osteoporosis group compared with that of normal group,but PICP decreased while ICTP had no significant difference compared with that of young male group.Conclusion The bone turn-over in postmenopausal osteoporosis is characterized by high absorption and high formation,but the absorption is over formation. In middle-aged male osteoporosis ,the level of bone formation is low and absorption is high .Measurements of PICP and ICTP is helpful to early osteoporosis diagnosis.