nm23-H1蛋白在原发性胆囊癌中的表达及临床价值探讨

Expression and Significance of nm23-H1 Gene Protein in Gallbladder Carcinomas

目的 探讨转移抑制基因nm 2 3 H 1在原发性胆囊癌中的表达及其与临床病理参数的关系。方法 本研究包括 45例胆囊癌和 15例胆囊息肉样病变 ,相关临床病理资料如组织学类型、分化程度、临床分期、浸润深度、局部淋巴结转移及肝脏浸润等一并记录。用免疫组化SABC法检测上述病变的nm 2 3 H 1表达。结果 胆囊癌的nm 2 3 H 1阳性表达率为 46 .7%,胆囊息肉样病变的阳性表达率为 13.3%,两者比较有显著性差异 (P <0 .0 5 ) ;且其表达与胆囊癌分化程度、Nevin分期、浸润深度及有无淋巴结转移均密切相关。结论 nm 2 3 H 1蛋白表达可能有助于区分胆囊良恶性病变 ,对胆囊癌的临床分期、浸润转移的估计和病人预后的判断有重要的意义。

Objective To study the relationships between protein expression of nm23?H1 and clinical-pathological parameters in gallbladder carcinomas in order to evaluate its significance in clinical practice.Methods Gallbladder carcinomas (n=45) and polypoid lesions of the gallbladder (n=15) were in this study.The protein expression of nm23?H1 was tested by immunohistochemistry methods.All clinical-pathological data such as histological type,grade of differentiation,level of infiltration,liver invasion and lymph node involvement,etc.were recorded.Results The positive percent of nm23?H1 prote in was obviously higher in gallbladder carcinomas than that in polypoid lesions of the gallbladder (P<0.05).The significant relationships were also found between nm23?H1 expression and degree of differentiation,Nevin stage,infiltration level or local lymph node invasion (P<0.05).Conclusion nm23?H1 examination could help to differentiate malignant lesions of the gallbladder from benign ones and might be acted as a significant clinical indicator for the judgement of invasion, metastasis and for the estimation of prognosis in gallbladder carcinoma cases.