血清总胆汁酸检测在肝炎后肝硬化中的意义

SIGNIFICANCE OF DETERMINATION FOR TOTAL BILE ACID IN SERUM IN POSTHEPATITIC CIRRHOSIS

评估血清总胆汁酸 (TBA)检测在肝炎后肝硬化诊断及判定预后中的意义。方法 :将 79例肝硬化患者根据ChildPuph分级分 3组 ,比较各组间血清TBA、TBil等值的差异及相关性 ,经治疗 2月后再次ChildPuph评分 ,根据不同预后 (好转、恶化包括死亡 )分组比较TBA等值。结果 :肝炎后肝硬化患者血清TBA异常率高 ,值随Child分极而递增 ,预后较好组TBA值较低。讨论 :血清TBA值能较特异地反应肝脏摄取、合成功能和分泌状态 ,在肝硬化诊断及判断预后中有一定的临床意义。

Objective:To study the measurement of total bile acids (TBA) in serum in patients with posthepatitic cirrhosis,and its application of diagnosis and judging prognosis.Methods:79 cases of posthepatitic cirrhosis were classified in three groups by the degree of Child Puph.the levels of TBA?TBIL?ALT,et al.of three groups were compared.2 months after therapy,the levels of TBA?TBIL?ALT,et al were observed again according to the degree of Child Puph which was reevaluated.Results:TBA in these cases was higher than other indicators,and its level increased with the degree of Child Puph.Lower TBA level occured under condition of better prognosis.Conclusions: Determination for TBA could specially show the state of metabolism of the liver and the TBA in serum was a excellent indicator of liver function in postepatitic cirrhosis.