长期低剂量喂饮稀土Y对小鼠内脏组织中微量元素含量的影响

Effect of Rare Earth in Drinking Water on Trace Element in Tissues s of Mice

通过在饮水中加入稀土钇 (0 ,2 3.2 5mg/L ,2 32 5 .0 0mg/L)使小白鼠长期摄入稀土 ,7个月后用POEMS测定子代小鼠肝、脾、肾中微量元素Cu、Zn、Fe、Mn、Co、Ca、Mg、Ni、Na等的含量。结果显示 ,F1子代小鼠组织中Ca、Fe、Co、Mn、Ni、Na含量均有不同程度的变化 (P <0 .0 5 ,或P <0 .0 1) ,但Cu、Zn、Mg含量未发生明显变化。提示稀土钇的长期摄入可造成小鼠体内某些微量元素的吸收和分布的变化 ,这种变化可能是稀土生物效应的机制之一。

The mice were fed with water dissolved different level Y 3+ (0,23.25mg/L,2325.00mg/L) for seven months, the level of trace elements such as Cu, Zn, Mn, Fe, Mg, Ni, Co in liver, spleen and kidney of F1 generation mice were then determined by POEMS. The results show that, compared with control, significant changes in level of Ca, Fe, Co, Mn, Ni Zn and Na(P<0.05 or P <0.01 ) were observed, but no change did in level of Cu, Mg in tissue. These results suggest that Y 3+ may have an effect on the absorption and distribution of some trace elements in tissue, which may be a cause of the biological effect of rare earth.