bcl-2、p53、c-myc蛋白在胃癌中表达的研究

Research on bcl-2, p53, c-myc proteim Expression in gastric carcinoma

目的 研究胃癌组织中 bcl- 2、p5 3、c- myc表达与其临床病理的相关性。方法 对有随访的不同分化的胃癌 5 0例、癌旁不典型增生粘膜病变 47例 ,及 2 0例正常胃粘膜进行免疫组化ABC法标记。结果 bcl- 2蛋白在癌旁轻、中、重度不典型增生的阳性率分别为 5 %、1 7.6 %、2 0 .0 % ,它们间无显著差异 P>0 .0 5 % ) ,在高分化胃癌中阳性率为 80 .0 %。与低分化的 5 0 .0 %相比 ,有显著差异 (P<0 .0 5 )。p5 3在高分化胃癌中阳性率为 5 0 .0 %。明显低于低分化的 84.6 % (P<0 .0 5 )。结论 bcl- 2和 p5 3可作为肿瘤分化和估计预后的主要参考指标之一。

Objective In order to study the correlation between expression of oncogene protein products bcl 2,p53,C myc and clinicopathological features in gastric carcioma .Methods 50 cases of different differentiated gastric carcinoma, 47 cases of peri tumor atypical mucasa hyperplasia and 20 cases of normal gastric mucosa were stained by immunnohistochemical ABC method. Results the positive rates of bcl 2 protein expression on mild, middle, severe peri tumor atypical hyperplasia were 5%, 17.6%, 20.0%, there was no obvious difference ( P >0.05); comparing the positive rate of well differentiated and poor differentiated gastric carcinoma 80.0%,50.0% respectively, there was obvious difference ( P <0.05),The positive rate of p53 protein expression on peri tumor mild atypicl hyperplasia was 45.0%,obviously lower than that of severe atypical hyperplasia 80.0%( P <0.05),while the positive rate of well differentiated gastric carcinoma was 50.0%,obviously lower than that of poor differentiated gastric carcinoma 84.6%( P <0.05).Conclusions bcl 2and p53 can be one of important index for tumor differentiateon and prognosis evaluation.