肝癌高危人群定群研究的病因和临床意义

Etiological and Clinical Significance of Cohort Study among High Risk Population of Primary Liver Cancer

目的 探讨原发性肝癌 (肝癌 )与乙型肝炎病毒 (HBV)的关系以及对肝癌高危人群定期观察的临床意义。方法 在肝癌高发现场 ,对肝癌高危人群和对照人群进行前瞻观察。结果 (1 ) HBs Ag携带组肝癌年平均发生率为 91 0 .89/ 1 0万 (4 6 / 5 0 5 0 ) ,相对危险性为 HBs Ag阴性组(2 4.2 4/ 1 0万 ,1 / 41 2 6 )的 37.5 8倍。 (2 )肝癌患者的平均生存期为 1 0个月 ,1、2年生存率分别为36 .1 7% (1 7/ 47)、6 .38(3/ 47) ,优于当地肝癌生存时间。结论 (1 ) HBV感染是肝癌发生的重要病因因素。 (2 )对肝癌高危人群定期进行 AFP和 B超检查 ,能早期发现肝癌病人 ,提高治疗效果。

Objective To investigate the correlation between HBV infection and occurrence of the primary liver cancer(PLC) and clinical significance of cohort observation among high risk population of PLC.Methods In the area of high risk of PLC a cohort observation between population of risk of PLC and control had been carr ied out by us.Results (1) The average year incidence rate in HBsAg carrier group is 910.89/100 000(46/5 050), and its relative risk of PHC incidence is 37.58 time of the relative risk in HBsAg negative group(24.24/100 000,1/4126).(2) The average survival period of PLC is ten months and the survival rate of 1 year?2 year is 36.17%(17/47)and 6.38%(3/47)respectively. These date is superior to those of the other PLC patients in this area.Conclusion (1)HBV infection is an important etiological factor in the development of PLC.(2)the cohort observation is the best program of screening early PLC patients and can improve treating effective in the among high risk population of PLC.