子宫颈癌中癌基因产物c-Fos、c-Jun的表达及意义

EXPRESSION AND CLINICAL IMPLICATION OF ONECOGENE PRODUCTS C-FOS AND C-JUN IN CARCINOMA OF CERVIX

目的 :探讨癌基因c fos、c jun表达产物与子宫颈癌的发生 ,发展及预后的关系。方法 :用免疫组化SABC法 ,以兔抗c fos、c jun抗体标记 6 0例子宫颈癌和 30例子宫颈上皮不典型增生 ,观察其分化程度和组织学类型 ,子宫颈癌的表达及阳性率比较。结果 :c fos、c jun阳性反应见于不典型增生上皮和子宫颈癌组织 ,不典型增生上皮c fos、c jun阳性率分别为 70 0 %和 5 0 0 %癌组织为 5 6 6 %和 4 8 3% ;在子宫颈癌表达的阳性率与癌组织分化程度和组织学类型有关 (P <0 .0 5 )。结论 :提示c fos、c

Objective:To determine the expression of c fos,c jun in carcinoma of cervix and its relationship with the development and prognosis of the tumor.Methods:Sixty cases of carcinoma of cervix and 30 cases of dysplasia of cervical epithelium were immunohistochemically stained for c fos,c jun.The positive rates in different grades and different types of carcinoma of cervix were also studied.Results:c fos,c jun immunoreactivity was found in carcinoma of cervix and dysplasia of cervical epithelium.The positive rates in dysplasia were 70.0% (c fos) and 50.0% (c jun),in carcinoma of cervix were 56.6% (c fos) and 48.3% (c jun).In carcinoma of cervix,the positive rates were related to different differentiation and histologic type ( P <0.05).Conclusion:The results suggest that over expression of c fos,c jun can occur in dysplasia of cervical epithelium and cancer tissue.