肝癌和肝硬化患者TTV感染的研究

Infection with a DNA Virus(TTV) in hepatocarcinoma and hepatocirrhosis patients

目的 :了解肝癌和肝硬化患者输血传染病毒 (transfusiontransmittedvirus ,TTV)感染状况。方法 :采用套式PCR技术检测及血清稀释法检测血清TTV滴度。结果 :肝癌中TTV阳性为山东临沂 8例 (8/ 2 5 )、广州 6例 (6/ 16)、广西 2 8例 (2 8/ 65 ) ;肝硬化中TTV阳性为 6例 (6/ 16)。结论 :本组肝癌和肝硬化患者中 39.3%的TTV感染 ,TTV感染可能对肝癌。

Objective To explore the infection condition of TTV in hepatocarcinoma and hepatocirrhosis patiients.Methods Adopt the nested-PCR technique to exemine the TTV and to test the titer of TTV With dilution of serum.Results In Linyi,Shandong Province,among 25 patients with hepatocarcinoma,TTV was positive in 8 cases;In Guang zhou,6 cases were positive In 16 patiens;in Guang xi,TTV was positive in 28 cases among 65 patients with hepatocarcinoma;Among 16 hepatocirrhosis patients,TTV was positive in 6 cases.Conclusion In hepatocarcinoma and hepatocirrhosis patients in this group,the infective rate of TTV was 39 3%,the infection with TTV may has a promotive effect to the hepatocarcinoma and hepatocirrhosis.