大肠癌中IGF-IR的表达及其临床意义

The Expression of Insulin-like Growth Factor-1 Receptor of Colorectal Carcinoma and its Clinical Significance

目的 :研究国人大肠癌中胰岛素样生长因子Ⅰ型受体 (IGF IR)的表达情况及其临床意义。方法 :采用免疫组织化学方法对 5 4例大肠癌和相应的正常大肠黏膜及其 14例转移淋巴结中IGF IR和增殖细胞核抗原 (PCNA)的表达情况进行检测和分析。结果 :① 33.3% (18/ 5 4 )的大肠癌IGF IR呈强表达 ,78.6% (11/ 14)的转移淋巴结呈强表达 ,而正常大肠黏膜仅 3.7% (2 / 5 4 )呈强表达 ,P <0 .0 0 5。②Ⅲ、Ⅳ期大肠癌IGF IR强表达率为 5 3% (9/ 17) ,而Ⅰ、Ⅱ期大肠癌的强表达率为 2 4 % (9/ 37) ,P <0 0 5。有淋巴结转移的大肠癌IGF IR强表达率为 5 6% (9/ 16) ,无淋巴结转移者强表达率为 2 4 % (9/30 ) ,P <0 .0 5。结论 :IGF IR在大肠癌形成过程中起重要作用 ,故检测IGF IR对大肠癌的诊断有帮助。IGF IR促进大肠癌的浸润和转移 。

Objective To evaluate the overexpression of insulin like growth factor 1 receptor (IGF 1 R) and its correlation with occurrence and development of colorectal carcinoma.Methods The colorectal carcinoma data base was from 54 patients and correspondent normal mucosa and 14 transitional lymphaden.The IGF 1 R expression on the tumor tissue slide was tested by immunohistochemistry.Each slide was rated on four scales:-,+ or ,,of which the two latter were considered as overexpression.Results Overexpression of insulin like growth factor 1 receptor(IGF 1 R) was found in 33.3%(18/54)of colorectal carcinoma,and its overexpression was found in 78.6%(11/140) of transitional lymphaden,while overexpression in normal mucosa was found only 3.7%(2/54), P <0.005.Overexpression of IGF 1 R was found in 53%(9/17) of colorectal carcinoma in Ⅲ,Ⅳ stage while it was found in 24%(9/37), P <0.05 of colorectal carcinoma in Ⅰ,Ⅱstage.Overexpression of IGF IR was found in 56%(9/16) of colorectal carcinoma with transitional lymphaden,and was found only in 24%(9/30)without transitional lymphaden, P <0.05.Conclusions IGF IR played an very important role in the development of colorectal carcinoma.So it was helpful to the diagnosis of colorectal carcinoma to test IGF IR.IGF IR could help to infiltrate and transfer of colorectal carcinoma,and therefore it was one of the potential index of colorectal carcinoma transference.