颌面颈部恶性淋巴瘤临床分析

A Clinical Analysis for Malignant Lymphoma in Maxilloface and Neck

目的 :探讨颌面颈部恶性淋巴瘤 (ML)的诊断方法与治疗措施。方法 :回顾分析 1991年 10月～2 0 0 0年 10月收治的ML患者 68例临床资料。结果 :男 4 2例 ,女 2 6例 ;年龄 11～ 67岁 ,中位年龄 4 6岁。霍奇金病 (HD) 5例 ,非霍奇金林巴瘤 (NHL) 63例。 4 1例患者采用综合治疗 ,2 7例采用单纯化疗或放疗。68例患者 1、3、5年生存率分别为 4 4 12 %、19 12 %和 13 2 3% ,存活患者中以临床Ⅰ、Ⅱ期者占绝大多数 ,死亡患者中以Ⅲ、Ⅳ期为多。结论 :颌面颈部ML发病率有增长趋势 ;对颈部原因不明的淋巴结肿大应反复活检以明确诊断 ;综合治疗是最为有效的治疗手段 ;

Objective To investigate the diagnosis and treatment of malignant lymphoma (ML) in maxilloface and neck.Methods From October of 1991 to October of 2000,68 patients (42 male and 26 female) with ML in maxilloface and neck admitted in our department.Results 5 cases were Hodgkin's disease (HD) and 63 cases non Hodgkin's lymphoma (NHL),41 cases accepted systemic treatment,27 cases chemotherapy or radiotherapy only.The survival rate of 1,3 and 5 years for 68 patients was 44 12%,19 12% and 13 23%.Among survivals,most were Ⅰand Ⅱstage clinically,while in those dead patients,most belonged to Ⅲ and Ⅳ stage.Conclusions There was an significantly increasing trend for incidence of ML in maxilloface and neck and repeated biopsy should be carried out if unclear mass in these regions.Chemotherapy combined with radiotherapy and operation is still the effective therapeutic means.The clinical staging classification is worth the prognosis.