动脉硬化性脑梗塞红细胞免疫功能的初步研究

Studying on Red Cell Immune function in Arteriosclerotic Cerebral Infarction

目的探讨红细胞免疫功能与动脉硬化性脑梗塞的关系。方法采用免疫测定法检测２０例脑动脉硬化患者、３８例动脉硬化性脑梗塞患者、３５例健康对照者的红细胞 Ｃ３ｂ受体花环率（ＲＢＣ－Ｃ３ｂＲＲ）和红细胞免疫复合物花环率（ ＲＢＣ－ ＩＣＲ）。结果脑梗塞 ＲＣＢ－Ｃ３ｂ ＲＲ低于正常对照组（ Ｐ＜０．００１），而ＲＢＣ－ＩＣＲ高于正常对照组（Ｐ＜０．００１），红细胞Ｃ３ｂ受体活性降低与脑梗塞灶大小呈负相关性（ｒ＝－０．６５， Ｐ＜０．０１）。结论红细胞免疫功能与动脉硬化性脑梗塞发病有关。

Objective To study the correlation between the red cell immune function and arteriosclerotic cerebral infarction (ACI). Methods RBC - C3bRR and RBC - ICR were determined in 20 cases of cerebral arteriosclerosis, 38 cases of arteriosclerotic cerebral infarction and 35 normal control subjects by immune method. Results The RBC - C3bRR in ACI was lower than that of control(P < 0. 001 ). The activity of RBC - C3bRR was negative correlated with infarct size on brain CT scans in ACI(r =- 0. 65, P < 0. 01 ). Conclusion Red cell immune function may effec on the development of ACI.