淋巴细胞抑素抑制小鼠GVHD作用及其机理研究

STUDY ON SUPPRESSIVE EFFECT OF LYMPHOCYTE CHALONE ON GRAFT-VERSUS-HOST DISEASE IN MICE AND ITS MECHANISM

本文采用小鼠GVHD模型,研究了淋巴细胞抑素对小鼠GVHD的抑制作用。结果表明,经淋巴细胞抑素体内外处理,可降低亲代鼠淋巴细胞在子一代F_1鼠产生移植物抗宿主反应的能力,使脾指数显著降低,骨髓移植后30天存活率提高及死亡动物平均存活天数延长。本文还对其抑制作用机理作了初步探讨,认为其GVHD抑制作用可能和抑制T、B林巴细胞功能及抑制IL-2的产生有关。

The suppressive effect of lymphocyte chalone on graft-versu3-host disease was investigated on the GVHD model in mice. The capacity of parental lymphoid cells to induce GVH reaction in F1 mice was reduced by pre-treatment with lymphocyte chalone in vivo and in vitro, expressed as significant decrease of spleen index, improvement of 30-day survival rate and medium survival time. We regard the probable mechanism involved as inhibition of T lymphocyte function and production of Interlukin-2.