摘要
甲醛化CJ-S_(131)辅以佐剂免疫小鼠,可诱导自身免疫反应。模型鼠出现的T、B细胞功能改变,血清出现高水平的自身抗体,在肝、肾、肠等组织出现的炎症性病理损伤,均类似于CJ-S_(121)慢性感染的小鼠。本模型优点在于实验周期短,用菌体抗原免疫小鼠代替复杂的感染过程,而诱导自身免疫反应。本模型可用于诸如免疫调节剂的筛选,自身免疫的分子机理等自身免疫反应的实验研究。
Autoimmunity can be induced in KM mice following immunization with formaldehyde treated Campylobacter jejuni (CJ-S131) and Freund's complete adjuvant. The phenomena of autoimmunity, including high level of autoantibodies in serum,hyperactivity of T and B cells, and inflammatory injuries in multiple organs such as intestine, liver and kidneys were found in experimental mice one month after first challenge with CJ-S131. These changes were quite similar to those found in CJ-S131 chronic infected mice. This model with its advantage of short experimental cycle and simplicity is very useful for studing the mechanism of autoimmunity and screening the immunoregulators.
出处
《上海免疫学杂志》
CSCD
北大核心
1991年第5期257-260,共4页
Shanghai Journal of Immunology
基金
国家自然科学基金
