一种经济有效的联萘酚的拆分方法

An economic and effective method for resolving the enantiomers of 1,1′-bi-2-naphthol

在前人的基础上改进了联萘酚 (BINOL)的拆分 ,可以很容易地同时得到联萘酚的 R和 S两个光学异构体 ,产率≥94 % ,e.e.值≥ 99% ,拆分剂氯化 (8S,9R) -(-) -N-苄基辛可尼定的回收率≥ 95 %

A simple and practical method has been developed to directly resolve racemic l,l′ bi 2 naphthol into both of its pure enantiomers with ≥94% yield and ≥99% e.e The chiral resolving agent,( 8S,9R) (-) N benzylcin chonidium chloride,is recovered in ≥95% yield