相转移催化D-甘露醇合成镇咳药左旋羟苯哌嗪

Phase transfer catalyzed synthesis of (-)-dropropizine with D-mannitol as starting material

采用新路线新工艺 ,以廉价易得的 D-甘露醇为原料 ,用相转移催化合成 ( +) -甘油醛缩丙酮、( +) -甘油醇缩丙酮。在 7种相转移催化剂 ( PEG和季铵盐系列 )中 ,PEG-4 0

This paper reports the synthesis of (-) dropropizine starting from D mannitol by using various PEG and quaternary ammonium salts as phase transfer catalyst.PEG 200 was found to be the best phase transfer catalyst.