咽部组织中P物质血管活性肠肽含量与OSAS患者咽腔狭窄的关系

The relationship between content of substance P、VIP in pharyngeal tissue and narrow pharyngeal cavity of patients with OSAS

目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)患者咽组织中P物质 (SP)、血管活性肠肽 (VIP)的含量与咽腔狭窄的关系。方法 :对 30例OSAS患者用半定量方法检测咽组织中SP和VIP的含量并与 12例健康成人的咽组织进行对照。结果 :OSAS患者咽组织中的粘膜上皮层、小血管内皮层、平滑肌周围、腺泡及腺导管周围 ,均有SP、VIP分布 ;其含量与对照组比较明显增加。结论 :咽部SP、VIP增多引起咽组织肿胀加重 ,OSAS患者咽腔狭窄 ,提示神经源性炎症是参与OSAS发病的重要因素之一。

Objective:To investigate the relationship between content of substance P?VIP in the pharyngeal tissue and narrow pharyngeal cavity of patients with OSAS.Method:By using semi quantitative immunohistochemical method,resected pharyngeal tissue from 30 patients with OSAS and 12 normal health adult controls were investigated with rabbit anti substance P and rabbit anti VIP.Result:SP and VIP were detected in tribution within the epithelium or between epithelium cells,around the pharyngeal glands and gland ducts,around endothelium cells and smooth muscle of blood vessels.SP and VIP levels in pharyngeal tissue of the patients with OSAS were increased than those of the controls.Conclusion:Narrow of pharyngeal cavity with OSAS was relative to edema of pharyngeal tissue induced by increased SP and VIP in pharyngeal tissue.A neurogenic inflamation was one of the factors of OSAS.