北京市老年人Alzheimer病与痴呆家族史关系研究

A Study on Family History of Alzheimers Disease in Beijing

目的 探讨Alzheimer病 (AD)和痴呆家族史的关系。方法 采用以人群为基础的病例对照研究设计 ,通过分层分析和Logistic回归分析估计AD与其痴呆家族史之间的联系强度。结果 一级亲属有痴呆病史者 ,患AD危险性显著高于对照人群 (OR值为 2 82 ,P <0 0 1)。同时调整年龄和受教育程度后 ,一级亲属的痴呆家族史仍和AD的发生有显著联系 (调整后的OR值为 3 5 17,P <0 0 1)。结论 北京市老年人Alzheimer病存在家族聚集性。

Objective To explore the relationship between Alheimer*ss disease and its family history.Methods Stratified analyses and Logistic regression analysis were used to examine the association between AD and its family history exposure in 127 cases and 1060 controls from a population based case-control study.Results The risk of Alheimer*ss disease was significantly higher in those who had at least one first-degree relative with dementia compared with those who had no dementia relatives ( OR =2 82).Adjusted by age and education level,positive family history of dementia still associated with Alheimer*ss disease( OR =3 517).Conclutions This study provides evidnce for family aggragation of Alzheimer*ss disease among the old people in Beijing.