胰蛋白酶原-2在急性胰腺炎临床诊断中的应用

Comparative analysis among Trypsinogen-Ⅱ, p-Amylase and α-Amylase for the diagnosis of acute pancreatits

目的用胰腺淀粉酶 (P- Amy)和淀粉酶 (α- Amy)与尿胰蛋白酶原 - 2进行对比分析 ,探讨胰蛋白酶原 - 2在急性胰腺炎时的临床诊断价值。方法急性胰腺炎 (AP) 6 9例 ,非胰腺炎 (NAP) 31例 ,采用免疫层析法测定尿胰蛋白酶原 - 2 ,免疫抑制法测定胰腺淀粉酶 ,酶偶联法测定α-淀粉酶。结果 6 9例急性胰腺炎中有 6 5例尿胰蛋白酶原 - 2阳性 ;6 3例胰腺淀粉酶阳性 ,5 9例α-淀粉酶阳性。尿胰蛋白酶原 - 2的诊断敏感度是 94.2 %,特异性是 90 .3%。胰腺淀粉酶诊断敏感度是 91.3%,特异性是 87.1%,α-淀粉酶的诊断敏感度是 85 .5 %,特异性是 74.2 %。结论尿胰蛋白酶原 -

Objective To discuss the clinical diagnosis value of trypsinogen Ⅱ in acute pancreatitis (AP) by the means of comparative analysis among trypsinogen Ⅱ, p Amylase, and uroamylase. Method Trypsinogen Ⅱ by immunostratographic analysis, p Amylase by immuno suppression and α Amylase by enzyme coupling reaction. in 69 samples with pancreatitis and 63 sampoles without pancreatisis were measured. Result Trypsinogen Ⅱ in 65 samples, p Amylase in 63 samples and α Amylase in 59 samples were positive. The diagnositic sensitivity of trypsinogen Ⅱ, p Amylase,α Amylase were 94 2%, 91 3% and 85 5%, respectively. The diagnositic specificity were 90 3%, 87 1% and 74 2% respectively. Conclusion Trypsinogen Ⅱ is a better index for the detection of acute pancreatitis.