反流性咽喉炎与胃食管反流病的关系研究

Study on relationship between the reflux laryngitis and gastroesophageal reflux disease

目的 :探讨反流性咽喉炎与胃食管反流病 (GRED)发生的关系。方法 :对 130例顽固的慢性咽喉炎患者行胃镜检查或 2 4h食管 pH监测 ,将检测的GRED随机分为两组 ,治疗组 :应用抑胃酸药、促动力药和清热解毒治疗 ;对照组 :单用清热解毒的咽喉炎药 ,对两组咽喉部症状缓解及内镜下病理改善情况进行统计学比较。结果 :检出GRED 45例 (34 .6 % ) ,反流性咽喉炎的体征多样化 ,治疗组 2 3例 ,有效率 91.3% (2 1例 ) ,对照组 2 2例 ,有效率 13.6 % (3例 ) ,P <0 .0 1。结论 :GRED是导致反流性咽喉炎的重要病因 ,抑酸剂与促动力药、清热解毒药合用 ,可缓解或改善反流性咽喉炎的症状和病理。

Objective:To investigate the relationship between reflux laryngitis and gastroesophageal reflux disease (GRED). Method:130 Patients of refractory chronic laryngitis with upper endoscopy and ambulatory 24 hr esophageal pH metry. The patients of gastroesophageal reflux disease were divided into two groups.Group A was treated with antacids and motiel medications. Group B was control. Result:45 ( 34.6 %) gastroesophageal reflux disease were found in 130 cases. 21 cases( 91.3 %)were healled in group A. 3 of 22 cases ( 13.6 %) were healled in control (P< 0.01 ).Conclusion: The gastroesophageal reflux disease was an important cause of the reflux laryngitis which symptoms and signs can be healled by antacids and motiel medications.