汉防己甲素和磷酸羟基喹哌联合用药治疗早期矽肺疗效观察

Study on Treatment of Early Stage Silicosis by Combined Therapeutics of Tetradrine and Quinolyl-Piperazine Hydroxyl Phosphate

目的 探索汉防己甲素和磷酸羟基喹哌联合用药治疗早期矽肺的疗效。方法 治疗组 15人 ,其中 0 + 7人 ,矽肺I 8人。汉防己甲素 2 0 0mg/d,10 0mg,p o ,bid ,每周服用6d ;磷酸羟基喹哌 0 5 g,p o ,每周 1次。服用 3个月后休息 1个月为 1个疗程 ,共治疗 6个疗程 ,为期 2年。对照组 15人 ,0 + 7人 ,矽肺I 8人 ,应用安慰剂 ,每次 2片 ,每周 2次 ,疗程同治疗组。结果 用药 2年后 ,临床症状改善 ,机体抵抗力增强 ,肺功能改善都优于对照组 ,血清铜蓝蛋白 ,血清肿瘤坏死因子经治疗后较治疗前降低 ,与对照组相比 ,差异有显著性。结论 说明早期矽肺抗纤维化治疗是有一定疗效的 ,而且无任何副反应 。

Objective\ Therapeutic effect for early stage silicosis by combined therapeutics of tetradrine(TD)and quinolyl\|piperazine hydroxyl phosphate(QOHP)was observed.Methods\ The observed group consisted of 15 early stage silicotics(7 of 0 + and 8 of stage Ⅰ).The dosage of TD was 100 mg,two times/day and 6 days a week.The dosage of QOHP was 0\^5 g/week.A course of 3 months followed by an intermittence of one month,and a total of 6 courses lasted for two years.The control group consisted of 15 silicotics(7 of stage 0 + and 8 of stage Ⅰ),and was given placebo.Results\ After two years treatment,the clinical symptoms,lung function and resistance to diseases were obviously improved in observed group than in the control group.At the same time,serum CP and TNF were significantly lowered.Conclusions\ In some extent,the anti\|fibrosis treatment for the early stage silicotics appeared effective without any side effect.