活血利水汤对大鼠肾病模型的作用

Effect of Huoxue Lishui Decoction on Rat Models of Nephrotic Syndrome

【目的】探讨活血利水汤 (由益母草、牛膝、白茅根、茯苓、白术、泽兰、桂枝、甘草组成 )治疗肾病综合征 (nephroticsyndrome ,NS)的作用机理。【方法】采用阿霉素肾病模型 ,设立正常对照组、模型对照组、泼尼松治疗组、活血利水汤治疗组和活血利水汤加泼尼松治疗组。用药 6周后 ,选取 2 4h尿蛋白定量、血液流变学、血内皮素、血清白蛋白、胆固醇、尿素氮及肌酐作为观察指标。【结果】活血利水汤治疗组、活血利水汤加泼尼松治疗组与模型对照组比较 ,能明显减少 2 4h尿蛋白定量 ,降低血清肌酐、尿素氮、血内皮素和血液高凝状态 ,提高血清白蛋白含量 (P <0 .0 5或P <0 .0 1) ;与泼尼松治疗组比较 ,血液流变学、血内皮素各指标有不同程度降低 (P <0 .0 5或P <0 .0 1)。【结论】大鼠肾病模型血液呈高凝状态 ,血内皮素增高 ;活血利水汤有改善血液高凝状态、降低血内皮素值和减轻肾脏功能损害的作用。

Objective To explore the mechanism of Huoxue Lishui Decoction(HLD)for nephrotic syndrome.Methods Seventy-five model rats with adriamycin-induced nephrotic syndrome were randomly allocated to five groups:Group A(treated with HLD),Group B(treated with HLD and prednisone),Group C(treated with prednisone),Group D(model control)and Group E(normal control).After a treatment course of 6 weeks,indexes of hemorheology,serum levels of endothelin,albumin,total protein and cholesterol,blood urea nitrogen and creatinine were observed.Results Most indexes in Group A and Group B were improved as compared with Group D(P< 0.05? or P< 0.01);indexes of hemorheology and endothelin level were decreased as compared with Group C(P< 0.05? or P< 0.01).Conclusion The increase of endothelin level indicates the blood of rat models is in a high coagulation state,and HLD can improve the high coagulation state by decreasing the endothelin level and reducing the damage of renal function.