HLA-B_(27)检测对强直性脊柱炎诊断的价值

Diagnostic Value of HLA-B_(27) for Ankylosing Spondylitis

【目的】评价人白细胞抗原B2 7(HLA -B2 7)对诊断强直性脊柱炎 (AS)的价值。【方法】选择 92例AS确诊病人作病例组 ,70例非AS病人为对照组 ,均采用美国国立卫生院 (NIH)微量淋巴细胞毒试验技术定性检测其HLA -B2 7含量。【结果】HLA -B2 7检测对诊断AS的敏感性为 87.0 % ,特异性为 91.4 % ;随机人群试验后HLA -B2 7阳性的患病概率为 2 .5 7% ;当患病概率为 5 0 %时 ,试验后HLA -B2 7阳性患病概率为91.0 1%。【结论】HLA -B2 7检测对AS有重要的辅助诊断价值 ,但不能用作AS的确诊标准。

Objective To evaluate the diagnostic value for ankylosing spondylitis (AS).Methods Ninety-two patients with confirmed diagnosis of AS were allcated to Group A and 70 non-AS cases served as the control(Group B).Human leucocyte antigen B 27(HLA-B 27)was determined by micro-lymphocytoxicity test.Results The sensitivity and specificity of HLA-B 27 in diagnosing AS were 87.0% and 91.4% respectively.In a randomized human group,the morbidity rate of AS was 2.57% for those with HLA-B 27 being positive.In clinic,when the assumed morbidity rate of AS was 50%,the morbidity rate arrived at 91.01% for the cases of HLA-B 27 being positive.Conclusion HLA-B 27 is an important accessory diagnostic index for AS,but it can not be ued as a confirmed diagnostic index for AS.