低分子量肝素用于不稳定性心绞痛、急性非Q波心肌梗死的疗效分析

Treatment of acute coronary syndrome with low molecular weight heparin.

目的 :比较不同抗栓方案对急性冠状动脉综合征的疗效。方法 :回顾性统计用普通肝素组 (A组 )与低分子量肝素组 (B组 )治疗期间心绞痛发作次数 ,硝酸酯类应用 ,出血与否及其程度、心肌梗死例数、血小板 (Plt)变化。结果 :两组用药期间 ,B组较A组心绞痛发作次数减少且需服用硝酸甘油以缓解胸痛者少 ,心梗发生率明显下降 ,仅A组有 1例Plt减少 ,B组轻度出血较A组明显低 ,两组均没有大出血及致死性出血。结论 :低分子量肝素在急性冠状动脉综合征中抗凝抗栓作用肯定 ,效果稍优于普通肝素 ,且更少发生出血 ,应用简便、安全。

Objective:To study the effect of different anticoagulant therapies for acute coronary syndrome.Methods:To analyse retrospectively the incidence of angina pectoris during the period of treatment with standard heparin(group A) and low molecular weight heparin (group B),also the use of nitroglycerin,and the change of platelet concentration (PLA).Results:The incidence of angina pectoris decreased in group B compared with that of group A,the need of oral nitroglycerin for pain relief also reduced,the ratio of myocardial infarction events reduced significantly,PLA reduced only in one patient,mild bleeding reduced significantly.No heavy and deadly bleeding occurred in both groups.Conclusions:The anticoagulation effect of low molecular weight heparin is superior to standard heparin,safe and easy to use.