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急性早幼粒白血病(APL)病人服用硫化砷后的血尿发砷测定 被引量:4

Determination of arsenic in blood 、urine and hair of acute promyelocytic leukemia(APL) patients after taking arsenic sulfides
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摘要 目的 :通过对急性早幼粒白血病 (APL)病人服用硫化砷后的血、尿及发中砷浓度进行测定 ,对急性早幼粒白血病人服用硫化砷后体内砷吸收及蓄积水平进行评估。方法 :氢化物 -原子吸收法。结果 :服药期病例服用硫化砷 1 .5 g以上 ,服药 8d以上 ,血砷平均水平为 5 3 .0±2 2 .5 (n=48) μg/L(1 4.7~ 1 40 .4μg/L) ,尿砷平均水平为 1 73 3 .6± 1 3 6 5 .9(n=44) μg/L(3 92 .6~ 6 847.1μg/L) ,尿砷排出量为 3 .93± 2 .44(n=3 2 ) mg/d(1 .1 4~ 1 1 .8mg/d)。停药期病例 ,停药 8d以上 ,血砷平均水平为 1 5 .3± 8.8(n=5 7)μg/L(2 .0~ 43 .5μg/L) ,尿砷平均水平为 2 3 2 .9± 2 5 7.3 (n=5 2 )μg/L (8.8~ 1 1 6 0 .7μg/L) ,尿砷排出量为 0 .3 3± 0 .3 0 (n=3 2 )mg/d(0 .0 1 9~ 1 .3 mg/d)。服药期病例血砷水平、尿砷水平及尿砷排出量水平均明显高于停药期病例 (P<0 .0 1 )。结论 :服用硫化砷 1 .5 g以上 ,服药 8d以上的服药期病例砷的吸收量为5 .6 1± 3 .48mg/d,停药 Objective:To detect arsenic in blood?urine and hair of APL patients after taking arsenic sulfides,and to estimate the absorption and retainment of arsenic in APL patients after taking arsenic sulfides.Methods Hydride generation-atomic absorption spectrometry.Results:APL patients taking arsenic sulfides over 1.5 g per day,longer than 8 days,the arsenic level in blood is 53.0±22.5(n=48)μg/L(14.7~140.4 μg/L),the arsenic level in urine is 1733.6±1365.9(n=44)μg/L(392.6~6847.1 μg/L),the arsenic excretion in urine is 3.93±2.44(n=32)mg/day(1.14~11.8 mg/day).APL patients who had stopped taking arsenic sulfides longer than 8 days,the arsenic level in blood is 15.3±8.8(n=57)μg/L(2.0~43.5 μg/L),the arsenic level in urine is 232.9±257.3(n=52)μg/L(8.8~1160.7 μg/L),the arsenic excretion in urine is 0.33±0.30(n=32)mg/day(0.019~1.3 mg/day).There is a significant difference of arsenic level in blood?urine and urine excretion between APL patients taking arsenic sulfides and APL patients having stopped taking arsenic sulfides(P<0.01).Conclusion:The APL patients can absorb arsenic 5.61±3.48 mg/day,after taking arsenic sulfides over 1.5 g per day,longer than 8 days.There was still arsenic in APL patients who had stopped taking arsenic sulfides longer than 8 days.
出处 《微量元素与健康研究》 CAS 2001年第4期15-17,共3页 Studies of Trace Elements and Health
关键词 硫化砷 急性早幼粒白血病 APL 尿 头发 诊断 药物浓度 Arsenic Arsenic sulfides APL
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参考文献6

  • 1W. A. Mhter. Some observations on the determination of total arsenic in biological tissues. Microchemical Journal,1989, (40): 132~135
  • 2H. Norin, M. Vahter A rapid method for the selective analysis of total urinary metabolities of inorganic arsenic Scand J Work environ Health, 1981, (7): 38~44
  • 3肖传方 陈清 等.微量元素与健康[M].北京:北京大学出版社,1989.182-192.
  • 4M. Vahter, G. Concha, B. Nermell, et al. A unique metabolism of inorganic arsenic in native Andean women. European J of phamacology, 1995, (293) .:455~462
  • 5J. L. Valentine, H. K. Kang,and G. Spivey. Arsenic levels in Human Blood, Urine and Hair in Response to Exposure via Drinking water. Environmental Research, 1979,(20) :24~32
  • 6K. Heydorn. Environment variation of arsenic levels in human blood determined by neutron activation analysis,Clin. Chim. Acta, 1970, (28): 347 ~349

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同被引文献16

  • 1沈继春,刘开彦,江滨,卢锡京,陆道培.四硫化四砷对急性早幼粒细胞白血病患者心电图QTc间期的影响[J].中华血液学杂志,2004,25(6):359-361. 被引量:4
  • 2王峰蓉,楼雅卿,陆道培.口服四硫化四砷临床药代动力学研究[J].中华血液学杂志,2005,26(1):44-46. 被引量:6
  • 3徐述,刘锋,麻柔.青黄散治疗骨髓增生异常综合征31例临床观察[J].中医杂志,2006,47(7):514-515. 被引量:21
  • 4肖志坚.循证医学指导下的血液病规范化诊治[J].中国实用内科杂志,2007,27(14):1091-1094. 被引量:18
  • 5Lu DP, Qiu JY, Jiang B, et al. Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood, 2002,99:3136-3143.
  • 6Soignet SL, Maslak P, Wang ZG, et al. Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxid. N Engl J Med, 1998, 339:1341-1348.
  • 7Shen ZX, Chen GQ, Ni JH, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): Ⅱ. Clinical efficacy and pharmacokinetics in relapsed patients. Blood, 1997, 89:3354-3360.
  • 8Unnikrishnan D, Dutcher JP, Varshneya N, et al. Torsade de pointes in 3 patients with leukemia treated with arsenic trioxide. Blood, 2001, 97: 1514-1516.
  • 9Lu DP,Qiu JY,Jiang B,et al. Tetra-arsenic tetra-sulfide for treatment of acute promyelocytic leukemia: a pilot report. Blood,2002,99: 3136-3143.
  • 10Lu DP, Wang Q. Current study of APL treatment in China. Int J Hematol,2002,76 Suppl 1:316-318.

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