摘要
目的 :通过对急性早幼粒白血病 (APL)病人服用硫化砷后的血、尿及发中砷浓度进行测定 ,对急性早幼粒白血病人服用硫化砷后体内砷吸收及蓄积水平进行评估。方法 :氢化物 -原子吸收法。结果 :服药期病例服用硫化砷 1 .5 g以上 ,服药 8d以上 ,血砷平均水平为 5 3 .0±2 2 .5 (n=48) μg/L(1 4.7~ 1 40 .4μg/L) ,尿砷平均水平为 1 73 3 .6± 1 3 6 5 .9(n=44) μg/L(3 92 .6~ 6 847.1μg/L) ,尿砷排出量为 3 .93± 2 .44(n=3 2 ) mg/d(1 .1 4~ 1 1 .8mg/d)。停药期病例 ,停药 8d以上 ,血砷平均水平为 1 5 .3± 8.8(n=5 7)μg/L(2 .0~ 43 .5μg/L) ,尿砷平均水平为 2 3 2 .9± 2 5 7.3 (n=5 2 )μg/L (8.8~ 1 1 6 0 .7μg/L) ,尿砷排出量为 0 .3 3± 0 .3 0 (n=3 2 )mg/d(0 .0 1 9~ 1 .3 mg/d)。服药期病例血砷水平、尿砷水平及尿砷排出量水平均明显高于停药期病例 (P<0 .0 1 )。结论 :服用硫化砷 1 .5 g以上 ,服药 8d以上的服药期病例砷的吸收量为5 .6 1± 3 .48mg/d,停药
Objective:To detect arsenic in blood?urine and hair of APL patients after taking arsenic sulfides,and to estimate the absorption and retainment of arsenic in APL patients after taking arsenic sulfides.Methods Hydride generation-atomic absorption spectrometry.Results:APL patients taking arsenic sulfides over 1.5 g per day,longer than 8 days,the arsenic level in blood is 53.0±22.5(n=48)μg/L(14.7~140.4 μg/L),the arsenic level in urine is 1733.6±1365.9(n=44)μg/L(392.6~6847.1 μg/L),the arsenic excretion in urine is 3.93±2.44(n=32)mg/day(1.14~11.8 mg/day).APL patients who had stopped taking arsenic sulfides longer than 8 days,the arsenic level in blood is 15.3±8.8(n=57)μg/L(2.0~43.5 μg/L),the arsenic level in urine is 232.9±257.3(n=52)μg/L(8.8~1160.7 μg/L),the arsenic excretion in urine is 0.33±0.30(n=32)mg/day(0.019~1.3 mg/day).There is a significant difference of arsenic level in blood?urine and urine excretion between APL patients taking arsenic sulfides and APL patients having stopped taking arsenic sulfides(P<0.01).Conclusion:The APL patients can absorb arsenic 5.61±3.48 mg/day,after taking arsenic sulfides over 1.5 g per day,longer than 8 days.There was still arsenic in APL patients who had stopped taking arsenic sulfides longer than 8 days.
出处
《微量元素与健康研究》
CAS
2001年第4期15-17,共3页
Studies of Trace Elements and Health