结节性甲状腺肿临床病理和免疫组化观察

Clinicopathologic and immunohistochemical observation of nodular goiter

目的 探讨结节性甲状腺肿（以下简称结甲肿）各组织学类型与激素功能的关系。方法使用常规ＨＥ染色及免疫组化ＰＡＰ法。结果 大多数胶质迢留结节中的Ｔｇ、Ｔ４、Ｔ３呈阴性；腺瘤型结节中的 Ｔｇ、Ｔ４、Ｔ３呈弱阳性，多数病例甲状腺组织染色反应不一致，胶质比滤泡上皮细胞染色稍强，多数病例Ｔ３是阳性，而Ｔ４为阴性。结沦 除了未成熟细胞类型以外，多数甲状腺组织结节具有激素功能，Ｔ３阳性组织占优势，是碘缺乏的代偿表现。

Objective It was studied the helation of the nistological types in nodular goiter to hormonal function. Method It was used by immunohistochemical PAP method. Result Tg、T4、T3 of colloid retention nodules showed posi- tive ,but T4 was negative in most Cases; adenomatous nodules showed positive Tg-T4&T3 being in less intensity. In most cases the staining reaction of the goitrous tissue was not uniform and less intense in colloid than in the follicular cells; in most cases T3was positive while much more cuses showed negative T4. Conclusion Most of the histological types in nodule goiter were hormonal functioning except that in that immecture cellular types. The predaminance of T3 positive tissue may be suggested as in compensating for iodine deficiency.