窒息缺氧与新生儿黄疸的关系

The relationship between apneic hypoxia and neonatal jaundice

目的观察窒息缺氧与新生儿黄疸的关系。方法测定 10 6例足月新生儿的血清胆红素值 ,并按轻度窒息缺氧组、重度窒息缺氧组和无窒息缺氧组分组进行比较。结果高胆红素血症发生率 3组分别为 2 8.6%、14 .7%、46.7% ,有显著性差异 (P<0 .0 5 ) ,其中重度窒息缺氧组明显低于无窒息缺氧组 (P<0 .0 1) ;血清胆红素 3组分别为 (184.7± 48.3 )μmol/L、(15 3 .2± 48.9)μmol/L、(2 0 9.6± 49.7)μmol/L,轻度窒息缺氧组低于无窒息缺氧组 (P<0 .0 5 ) ,重度窒息缺氧组明显低于轻度窒息缺氧组 (P<0 .0 1)和无窒息缺氧组 (P<0 .0 1)。结论窒息缺氧时氧自由基的产生可能使新生儿黄疸减轻。

Objective To observe the relationship between apneic hypoxia and neonatal jaundice.Methods Serum bilirublin was measured in 106 newborns of term birth, who were divided into 3 groups: mild, severe and non apneic hypoxia groups.Comparison was made among three groups.Results The incidence rates of hyperbilirubinemia were 28.6% , 14.7% and 46.7% in the three groups, respectively, with significant difference(P<0.05), which was obviously lower in severe apneic hypoxia group than in non apneic hypoxia group(P<0.01). Serum bilirublin levels were (184.7± 48.3) μmol/L, (153.2±48.9) μmol/L and (209.6±49.7) μmol/L in the three groups, respectively, which were lower in mild apneic hypoxia group than that in non apneic hypoxia group(P<0.05), and which was apparently lower in severe apneic hypoxia group than that in mild apneic hypoxia group(p<0.01) and non apneic hypoxia group(P<0.01).Conclusion Oxygen free radicals induced by apneic hypoxia may decrease the incidence rate of hyperbilirubinemia and alleviate neonatal jaundice.