摘要
目的 研究宫颈癌组织中 ｉＮＯＳ、ｅＮＯＳ的表达，探讨 ＮＯＳ与宫颈癌生物学行为的关系。方法 采用免疫组化法检测 ４０例宫颈鳞癌，１０例宫颈腺癌中 ｉＮＯＳ，ｅＮＯＳ的表达。结果ＮＯＳ的表达与宫颈癌病理类型、分化程度无关；ｉＮＯＳ及ｅＮＯＳ在宫颈癌Ⅱ期中的表达明显高于Ⅰ期（Ｐ＜０．０５）；在淋巴结转移组中的表达明显高于无淋巴结转移组（Ｐ＜０．０５）。结论ＮＯＳ对宫颈癌的生长、侵袭起促进作用，可作为预后的一项参考指标。
Objective To investigate expression of nitric oxide synthase(NOS)in cervical carcinoma and the relationship between the expression and the biological behaviors of cervical carcinoma. Methods: The iNOS and eNOS expression was examined using immunohistochemistry in 40 cases of squamous carcinomas and 10 adenocarcinomas. Results: The expression rate of NOS had no association with histologic classifica- tion and differentiation of cervical carcinoma,respectively(P>0. 05). The positive rate of NOS in cervical carcinoma with grade 11 was markedly higher than that in grade I (P<O. 05). The expressive rate of NOS in lymph node metastic group was significantly higher than that in nonmetastasis, (P<0. 05). Con- clusion:NOS may promote cervical carcinoma growth invasion. It抯 expression has relationship with prog- nosis of cervical carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
2002年第1期41-42,共2页
Cancer Research on Prevention and Treatment
关键词
一氧化氮合酶
宫颈癌
免疫组化
NOS
Nitric oxide synthase
Cervical carcinoma
Immunohistochemistry
