顺铂和5-氟尿嘧啶/醛氢叶酸双周疗法治疗晚期乳腺癌临床研究

The clinical study of bimonthly 5-Fluorouracil (5-Fu)/Leucovorin (LV) combined with cisplatin (DDP) in treatment of advanced breast cancer

目的观察顺铂（Ｃｉｓｐｌａｔｉｎ，ＤＤＰ），５－氟尿嘧啶（５－Ｆｌｕｏｒｏｕｒａｃｉｌ，５－Ｆｕ）／醛氢叶酸（Ｌｅｕｃｏｖｏｒｉｎ，ＬＶ）双周疗法治疗晚期乳腺癌的疗效及其毒性。方法病理明确的３６例晚期乳腺癌病人进入研究组，全组病人既往均行ＣＭＦ／ＣＡＦ方案化疗及常规放疗。治疗方法：ＬＶ２００ｍｇ／ｍ２，静脉输注２ｈ，后接５－Ｆｕ ３７５ｍｇ／ｍ２静推１０ｍｉｎ，再接５－Ｆｕ ３．０ｇ／ｍ２，用输液泵连续静脉输注４８ｈ，顺铂２５ｍｇ／ｍ２，ｄ１－２，静脉滴注，以上治疗每两周一次，２８天重复，所有病人至少接受２疗程的治疗。结果经过两周期的化疗，完全缓解（Ｃｏｍｐｌｅｔｅ ｒｅｍｉｓｓｉｏｎ，ＣＲ）２例（５．６％），部分缓解（ｐｒｔｉａｌ ｒｅｍｉｓｓｉｏｎ ＰＲ）１８例（５０％），１０例病人稳定（２７．７％），恶心、呕吐和骨髓抑制为主要不良反应，毒性相对较弱。结论顺铂和５－氟尿嘧啶／醛氢叶酸双周疗法治疗晚期乳腺癌缓解率高，毒性相对低。

ObjectiveTo evaluate the efficacy and to toxicity of DDP combined with himonthly 5-Fu in the patients with advanced breast cancer. MethodsThe patients with a histologic diagnosis of breast cancer were eligible. All patients were treated with CMF/CAF and conventional radiotherapy. The chemotherapy regimen was comprised of bimonthly 2-hour infusion of leucovorin 200mg/m2 followed by 10-minute intravenous bolus of 5-Fu 375mg/m2, then 48-hour infusion of 5-Fu 3.0g/m2using an ambulatory pump, Cisplatm 25mg/m2d1-2infusion. Every 28 days one cycles. All pationts were received at least two cycles of treatment. ResultsAfter two cycles of chemotherapy. 2 obtained complete remission (CR) (5.6%), 18 obtained partial remission (PR) (50%), 10 had stable disease (SD) (27.7%). Nausea vomiting and myelosuppression were mainly side effects. Toxicity was comparatively mild. ConclusionData from the current study indicated that bimonthly 5-Fu/LV combined with DDP had moderate activity but comparatively mild toxicity for advanced breast cancer.