肝动脉插管化疗与放疗交替进行治疗原发性肝癌

Hepatic artery intubatton chemotherapy and radiotherapy alternately to treat primary liver cancer

目的观察Ⅱ期不可手术切除的原发性肝癌施行肝动脉结扎、肝动脉插管化疗及常规分割放疗的疗效。方法全组６５例为经剖腹探查判定不可手术切除的Ⅱ期肝癌，取活检并作了肝动脉结扎、肝动脉插管化疗及常规分割放疗。结果ＡＦＰ定量下降１／２以上率、１、３、５年生存率分别为６７．６％、７３．９％、４１．５％、９．２％，ＰＲ率、二步手术切除率分别为７０．８％、１２．３％。结论采用肝动脉结扎、低剂量顺铂（ＰＤＤ）１０ｍｇ动脉化疗６天／周与常规分割放疗５天／周交替夹心、互为协同的治疗方案能有效地减轻症状、缩小瘤体、提高手术切除率、延长生存期，且操作较为简单，易于掌握。

ObjectiveTo observe the therapeutic effect of primary liver cancer patients which were stage Ⅱ use routine fractination radiation assisted with hepatic artery intubatton chemotherapy and hepatic artery ligation.MethodsAll patients were judged as impossible for surgical resection by exploratory lapsrotomy,and were stage Ⅱ,approved by pathology,and all were treated by routine fraction radiotherapy assisted with hepatic artery intubatton chemotherapy and hepatic artery ligation .Results There were 67.6%patients whose level of AFP reduced to half of its primary level,and one、three、five year survival rate were 73.9%,41.5% and 9.2% respectively ,and rate of PR and two step excision rate were 70.8% and 12.3%respectively .ConclusionRoutine fractination radiation assisted with hepatic artery intubatton chemotherapy and hepatic artery ligation ,use low dose cisplatin(PDD)10mg, 6days/week during artery chemotherapy and routine fraction radiotherapy 5 days/week alternately ,and cooperate with each other,is an effective and reasonable therapeutic scheme for treating impossible excision liver cancer.This scheme can ease the sympton effectively,reduce the tumor tissue,and increase excision rate and extend the survival time ,and also the operation is rather simple,and easy to master.