遗传性男性不育的进展
摘要
遗传因素是男性不育的主要病因之一,并可通过辅助生殖技术垂直传递给男性子代。相当数量的临床非特发性重度少精子或无精子患者有AZF缺失。与精子发生有关的基因大量集中在Y染色体长臂的AZF区。在男性不育临床有必要开展使用外周血细胞DNA的AZF检查。
参考文献6
-
1Cram DS, Ma K, Bhasin S, et al. Y chromosome analysis of infertile men and their sons concerived through intracytoplasmic sperm injection vertical transmisson of deletions and ranity of de novo deletion. Fertil Steril, 2000,74(5) :909-915
-
2Krausz C, Bussani-Mastellone C, Granchi S, et al. Screening for micriodeletions of Y chromosome genes in patients undergoing intracytoplasmic sperm injection. Hum Reprod, 1999,14:1717-1721
-
3Moro E, Marin P, Rossi A, et al. Y chromosome microdeletions in infertile men with valicocele. Mol Cell Endocrinol, 2000,161(1-2) :67-71
-
4Foresta C, Moro E, Garolla A, et al. Y chromosome microdeletion in cryptorchidism and idiopathic infertility. J Clin Endocrinol Metab, 1999,84(10): 3660-3665
-
5Krausz C, Quintana-Murci L, Barbaux S, et al. A high frequency of Y chromosome deletions in males with nonidiopathic infertility. J Clin Endocrinol Metab, 1999,84(10) :3606-3612
-
6van Golde RJ, Wetzels AM, de Graaf R, et al. Decreased fertilization rate and embryo quality after IC SI in oligozoospermic men with microdeletions in the azoospermia factor c rwegion of the Y chromosome. Hum Reprod, 2001,16(2) :289-292
-
1张玉兰,张新平,惠宏侠,金连弘.无精子症和严重少精子症134例遗传学分析[J].临床泌尿外科杂志,2004,19(3):172-174.
-
2周惠耕.3529例男性不育病因分析和诊治体会[J].临床泌尿外科杂志,1994,9(4):202-204. 被引量:3
-
3杨光毅.跟骨钢板固定治疗跟骨骨折的临床研究[J].中国民间疗法,2011,19(9):59-60. 被引量:1
-
4陈焕林,邵立民,周志权.腰椎间盘突出症手术效果不佳原因分析[J].浙江创伤外科,2005,10(2):120-120.
-
5蓝震宇.急性胰腺炎80例临床分析[J].现代中西医结合杂志,2009,18(19):2291-2292.
-
6高云,陈嘉昌,彭焕玉,朱振宇.Y染色体微缺失及其检测方法[J].分子诊断与治疗杂志,2011,3(5):326-329. 被引量:8
-
7郑贤红,王欣宇,云馨,马超,杨亚萍,刘睿智.长春地区425例非梗阻性无精子症患者AZF区微缺失分析[J].临床检验杂志,2010,28(3):232-233.
-
8任晨春.Y染色体缺失分析的预后价值——Y微缺失的范围对精子发生和支持细胞成熟的预后作用[J].国外医学(计划生育分册),2002,21(1):55-56.
-
9戴汝琳,刘睿智.Y染色体微缺失与男性不育临床表现的关系[J].中国计划生育学杂志,2008,16(3):186-188. 被引量:3
-
10郭浩,张畅斌,卢建.毛细管电泳结合标记PCR检测Y染色体AZF缺失[J].按摩与康复医学,2013,4(8):106-107.