子宫接受性基因调控的研究
摘要
胚胎着床是一个复杂的过程,涉及到着床胚泡和雌孕激素主导的子宫的分子相互作用。由于基因剔除技术的应用,有些基因被发现在胚胎着床过程中发挥重要作用。本文主要就发育调控基因—同源框基因在着床过程中的作用加以讨论,并进一步提出胚胎着床通路的基因调控的模式。
参考文献20
-
1Liang Ma, Mylene Yao, Richard L, et al. Genetic control of uterine receptivity during implantation. Semi Reprod Endocrinol, 1999, 17 (3):205-216
-
2Yong W, Pei Jun Z. On structure and function of homeodomain. Devel Reprod Biol, 1997, 6:81
-
3Krumlauf R. Hox genes in vertabrate development. Cell, 1994, 78:191
-
4Benson GV, Jim H, Paria BC, et al. Mechanisms of female infertility in Hoxa-10 mutant mice: Uterine homeosis versus loss of maternal Hoxa-10 expression. Development, 1995, 122:2687-2696
-
5Hsieh-Li HM, Witte DP, Weinstein M, etal. Hoxa-11 structure, extensive antisense transcription, and function in male and female fertility.Development, 1995, 121:1373-1385
-
6Satokata I, Benson GV, Maas RL. Sexullay dimorphic sterility phenotypes in Hoxa- 10 deficient mice. Nature, 1995, 374:460-463
-
7Gendron RL, Paradis H, Hsieh-Li HM, et al. Abnormal uterine stromm and glandular function associated with maternal reproductive defects in Hoxa-11 null mice. Biol Reprod, 1997, 56:1097-1105
-
8Ma L, Benson GV, LimH, etal. Abdominal B (AbdB) Hoxa genes:Regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev Biol, 1998, 197:141-154
-
9WangW, Van De Water T , LufkinT. Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development,1998, 125:621-634
-
10Pavlova A, Boutin E, Cunha G, etal. Msxl(Hox-7.1) in the adult mouse uterus: Cellular interactions underlying regulation of expression.Development, 1994, 120:335-345
-
1王莉芬,罗宏志,朱正美,王介东.同源框基因与着床[J].生殖与避孕,1999,19(6):323-327. 被引量:4
-
2陈辉.HOXA10与雌性生殖[J].国外医学(计划生育分册),2003,22(1):27-31.
-
3樊建设.维生素A和同源框基因与胚胎发育[J].国外医学(遗传学分册),1999,22(6):302-305. 被引量:4
-
4陈彪,范明,周长满,钟世镇.同源框基因islet-1表达产物在大鼠脑中分布的免疫组织化学研究[J].解剖学报,1997,28(2):161-164. 被引量:2
-
5丁晓虹,李统威,范明.同源框基因IsL-1在中枢神经系统中的表达[J].解剖科学进展,1997,0(3):94-94.
-
6韩杨,周崇治.同源框基因在消化道肿瘤中的异常表达及相关机制研究[J].国际外科学杂志,2012,39(6):396-399. 被引量:2
-
7陈彪,周长满,钟世镇,范明.ISL-1在大鼠海马分布的免疫组织化学研究[J].神经解剖学杂志,1998,14(1):78-80.
-
8李斌,丰有吉.激素对女性生殖道组织Hox基因表达的调控[J].国际生殖健康/计划生育杂志,2008,27(1):30-33.
-
9徐惠成,史常旭.黄体功能不全患者子宫内膜上皮细胞整合素β_3亚单位与孕激素受体关系[J].重庆医学,2001,30(3):213-214. 被引量:3
-
10马琪,陈昭典.同源框基因:肿瘤与发育间的桥梁[J].国际泌尿系统杂志,2006,26(1):72-75. 被引量:1