支扩方对支气管扩张症模型气道炎症及细胞因子影响

Effects of the Zhikuofang on the Inflammation and Cytostatics of the Airway Model of Bronchiectasis

目的 :探讨支扩方与氧氟沙星对支气管扩张症 (支扩 )模型气道炎症及细胞因子的影响。方法 :建立绿脓杆菌大鼠支扩模型 ,以支扩方与氧氟沙星进行干预 ,比较支扩方与氧氟沙星对支扩模型血炎症细胞密度、气道分泌物排泌量、气道冲洗液细菌量、气道组织细胞因子 (IL 8,TNF α)、气道组织病理学的影响。结果 :支扩方对炎症细胞密度、气道分泌物排泌量、气道组织IL 8,TNF α的作用优于氧氟沙星 (P <0 .0 5 )。而氧氟沙星对气道冲洗液细菌量的作用优于支扩方 (P <0 .0 5 )。两者对气道组织病理学影响的差异无显著性。结论 :支扩方可能是通过抑制气道组织IL 8,TNF α活性 ,减少气道分泌物排泌量 ,降低炎症细胞密度 ,减轻气道炎症反应 ,实现抗炎抑菌作用。

Objective: To explore the effects of Zhikuofang,a TCM prescription, and Ofloxacin on the inflammation and cytostatics of the airway model of bronchiectasis. Method: The airway model of bronchiectasis (AMB) was set up and infused with Ps.Aeruginosa. A comparison between the effects of Zhikuofang and Of loxacin on the AMB was made. Result: Zhikuofang is better than Ofloxacin in following aspects: lowering the density of inflammation cells in blood, decreasing the volume of tracheal secretion and inhibiting the cytostatics (IL 8 and TNF α) of the trachea tissue, but Ofloxacin is more effective in diminishing the amount of bacteria in trachea flushing liquor. There was no marked difference between them in their histopathy effects on the trachea. Conclusion: Zhikuofang probably plays antiphlogistic and bacteriostatic effects by inhibiting the IL 8 and TNF α,resisting secretion, decreasing the inflammation cells and resisting inflammation of trachea.