摘要
Pain and hyperalgesia occured when L 5 and L 6 spinal nerves were ligated. To ev aluate the electrophysiological changes that contribute to this sensory patholog y, whole cell current clamp recording was performed in DRGs that was obtained from neuropathic pain and control rats. After nerve ligation, action potential threshold reduced (more negative) in b oth small and median sized DRG neurons (-18.98±0.69 mV vs -11.12±1.06 mV in c ontrol small sized neurons; -19.44 ±2.22 mV vs -14.55±1.81 mV in control m edi an sized neurons), but resting membrane potential action potential duration at half amplitude (APD 1/2 ) and action potential amplitude did not change sign ifica ntly. In addition, obvious membrane potential oscillations were observed in smal l sized DRG neurons from neuropathic pain rats (P<0.05 compared with control group). These results suggested that neuropathic pain increased the exci tability of nociceptors, which may be an important mechanism underlying peripher al hypersensitivity.
Pain and hyperalgesia occured when L 5 and L 6 spinal nerves were ligated. To ev aluate the electrophysiological changes that contribute to this sensory patholog y, whole cell current clamp recording was performed in DRGs that was obtained from neuropathic pain and control rats. After nerve ligation, action potential threshold reduced (more negative) in b oth small and median sized DRG neurons (-18.98±0.69 mV vs -11.12±1.06 mV in c ontrol small sized neurons; -19.44 ±2.22 mV vs -14.55±1.81 mV in control m edi an sized neurons), but resting membrane potential action potential duration at half amplitude (APD 1/2 ) and action potential amplitude did not change sign ifica ntly. In addition, obvious membrane potential oscillations were observed in smal l sized DRG neurons from neuropathic pain rats (P<0.05 compared with control group). These results suggested that neuropathic pain increased the exci tability of nociceptors, which may be an important mechanism underlying peripher al hypersensitivity.
出处
《针刺研究》
CAS
CSCD
2001年第3期228-229,共2页
Acupuncture Research
