肝阴虚证患者血浆血栓素A_2、前列环素I_2水平研究

Studies on the Levels of Thromboxane B_2 and Prostaglandin I_2 In Plasma of Patients with Liver Yin Deficiency

为了比较慢性肝炎与其它疾病中肝阴虚证血浆血栓素B2 (TXB2 )和 6 -酮 -前列腺素F1α6 -Keto -PGF1α水平 ,用放射免疫法检测 2 8例肝阴虚证患者血浆TXB2 和 6 -Keto-PGF1α含量 ,又分慢性肝炎与其它疾病两组进行对比观测。结果表明 ,肝阴虚证患者血浆TXB2 水平、T/ 6 -K值显著高于健康对照组 (均P <0 0 1) ,6 -Keto-PGF1α水平显著低于健康对照组 (P <0 0 5 ) ,慢性肝炎组与其它疾病组TXB2 、T/ 6 -K值均显著高于健康对照组 (均P <0 0 1)、6 -Keto -PGF1a显著低于健康对照组 (均P <0 0 1) ,且两组组间比较差异无显著性 (P >0 0 5 )。提示肝阴虚证患者调节血管平滑肌舒缩功能的活性物质紊乱 ,存在微循环障碍。

The plasma thromboxane B 2(TXB 2) and 6 Keto PGF 1α(6 K) were determined by RIA in 28 patients with Liver Yin Deficiency (LYD) We compared the levels in 15 patients with chronic hepatitis (CH) and 13 patients with other diseases with the same syrdrome The results showed that the levels of plasma TXB 2、TXB 2/6 K of patients with LYD were significantly higher than those of the normal group ( P <0 01),and the levels of 6 Keto PGF 1α were lower than those of the normal group ( P <0 05). So did those of CH group and other diseases group ( P <0 01; P <0 01) There is no significant difference between these two groups ( P >0 05) The results suggest that patients with LYD have dysfunction of the active substance regulating vascular smooth muscle and disturbance of microcirculation