芳维A酸乙酯对细胞间隙连接通讯的影响

The effects of arotinoid ethylester on gap junctional intercellular communication

目的 研究芳维A酸乙酯对细胞间隙连接通讯的影响。方法 用划痕标记染料示踪技术检测黄色荧光素在培养细胞中的传递情况。结果 芳维A酸乙酯能够拮抗促癌剂TPA对GJIC的抑制作用 ,在一定范围内 ,芳维A酸乙酯浓度越大 ,其对NIH3T3细胞GJIC功能的恢复作用越强 ,因而具有抗促癌作用。结论 芳维A酸乙酯不仅具有抗增殖、诱导分化作用 ,同时还具有癌症的化学预防作用。

Objective The effects of arotinoid ethylester on gap junctional intercellular communication were studied on cultural cells.Methods The transmission of Lucifer Yellow in cultural cells was observed by the methods of scrape-loading dye transfer.Results This experiment illustrated that arotinoid ethylester could restrain the promoting agents.Conclusion It suggested arotinoid ethylester not only had the effects of anti-proliferation,inducing differentiation,but also had the effects of cancer chemoprevention.