尿毒症血透患者血浆瘦素与胰岛素水平的关系

The Serum Leptin Level of Hemodialysis Patients and the Relation to Insulin

应用放免法测定尿毒症血透患者及健康人 (各 3 0例 )血浆中瘦素、C肽及胰岛素水平。结果 :血透组血浆瘦素及C肽质量浓度明显高于对照组 (P <0 .0 1 ) ;瘦素质量浓度与体质量指数 (BMI)、C肽及胰岛素呈正相关 (P <0 .0 5 )。提示 :尿毒症维持性血透患者血浆瘦素及C肽质量浓度明显升高 ,瘦素与BMI。

This study investigated leptin levels of hemodialysis patients and the relation to insulin concentration. Thirty maintenance hemodialysis patients and thirty healthy control subjects were recruited for the study. Blood was drawn after an overnight fast. Serum leptin was measured with a human leptin RIA kit. C peptide and insulin were all measured with RIA kit. There were also blood tests to measure BUN, creatinine and glucose. Mean serum leptin concentration was significantly higher in the HD group than that of the control ( P <0.01). HD group have significantly higher concentrations of C peptide, BUN and creatinine ( P <0.01) than that of the contral group. Leptin levels in both groups correlated positively with BMI, C peptide and insulin ( P <0.05). The data suggests that leptin and C peptide are markedly increased in HD patients. Serum leptin correlates positively with BMI, C peptide and insulin.