热休克蛋白70与加速度应激

Heat Shock Protein 70 and Stimulation Induced by +Gz.

现代高性能战斗机产生的高G值持续性正加速度可导致脑缺血、缺氧 ,继而引起脑功能障碍。热休克蛋白 70 (heatshockprotein 70 ,HSP70 )是生物体中广泛存在的一种蛋白质 ,其表达与脑缺血中的应激反应有重要关系 ,与神经细胞的缺血性损伤密切相关 ,目前大多数研究认为应激时HSP70的表达对神经元有保护作用。本文综述了HSP70的生物学特性及其在脑缺血后对细胞保护作用 ,并阐述了HSP70的表达与 +Gz暴露强度的关系。

High sustained +Gz acceleration produced by modern high performance aircrafts can induce brain damage because of ischemia and hypoxia. Heat shock protein 70(HSP70)is one of the proteins broadly exist in organisms. The expression of HSP70 is an important reaction in the brain, and it has close relationship with brain ischemic injury. Now, the common view thinks that the expression of HSP70 during stimulation can protect nerve cells. This paper reviewed the biologic characteristics of HSP70 and the protective effect of HSP70 on nerve cells after brain ischemia. Also, the relationship of HSP70 expression and exposure value of +Gz were discussed.