神经母细胞瘤转化为节细胞神经瘤的临床观察

Clinical study on neuroblastoma transforming into ganglioneuroma

目的 了解神经母细胞瘤转化为良性的节细胞神经瘤的规律 ,总结经验 ,提出治疗方法。方法 回顾 1981年 1月～ 1998年 12月我院收治 10 3例神经母细胞瘤中 3例转化为节细胞神经瘤的治疗经过及组织学变化。结果 3例患儿至今生存 ,分别经过 2次以上手术 ,采用多药联合的强化化疗。组织学已改变成为节细胞神经瘤。结论 对神经母细胞瘤的治疗应积极 ,尤其对那些第一次手术不能完整切除肿瘤的患儿更应如此。对带瘤生存时间长 。

Objective To identify the pattern of neuroblastoma transforming into ganglioneuroma and find the treatment for the condition.Methods The histological changes and course of treatment were reviewed on 3 patients who had experienced tumor transformation. They were among 103 neuroblastoma patients admitted from 1981.1 to 1998.12.Results Three patients have all survived and received operations for over two times. Combined intensive chemical therapy was employed on them. Histological study showed change to ganglioneuroma.Conclusions Aggressive treatment should be adopted, especially for children in whom the complete removal of tumor can not be achieved by the first operation. For patients who had long tumor-loaded survival and good life quality, the possibility of neuroblastoma transforming into ganalioneuroma should be suspected.