摘要
采用改性乙烯-醋酸乙烯共聚物(mEVA)作为控释材料制备释放左炔诺孕酮(LNG)4μg/d,预期使用寿命为5年的钥匙形宫内节育器(IUD)。本IUD在体外和在人及动物子宫内均为零级释药。释药速度与释药管管壁厚度或管外内径比的对数成反比,提示本释药体系的释药模武符合膜控制释药的特性。动物血药浓度测定结果表明,家兔子宫内植入IUD 2d后,血中LNG浓度趋于稳定。
A key-shaped levonorgestrel-releasing intrauterine device (LNG-IUD) was designed and produced. The IUD was made of modified EVA copolymer and LNG paste was contained in a hollow vertical arm. In vitro and in vivo drug release patterns showed zero-order kinetics. The drug release mechanism of this system conforms to a membrane controlling nature. The LNG release rate of this IUD is about 4μg/day in woo and is proposed to be effective for 5 years.
出处
《上海医科大学学报》
CSCD
1991年第4期274-277,共4页
Journal of Fudan University(Medical Science)
关键词
宫内节育器
左炔诺孕酮
释放
intrauterine devise
levonorgestrel
controlled release
