血隆冲剂抗肝纤维化的临床与实验研究

Clinical and Experimental Study on Anti-Liver Fibrosis Effect of Xuelong Granule

目的 :研究血隆冲剂抗肝纤维化的临床疗效及其作用机理。方法 :肝硬变患者 98例 ,随机分为两组 ,治疗组 (5 8例 )和对照组 (4 0例 )分别给予血隆冲剂和参柴颗粒剂治疗 3个月 ,观察治疗前后两组患者血清透明质酸 (HA)、层粘蛋白 (LN)水平及肝脏病理组织学的改变。实验研究观察造模大鼠肝组织的羟脯氨酸含量及光、电镜下的肝脏病理改变。结果 :显效率和总有效率治疗组分别为 4 3 1%、72 4 % ,对照组分别为 17 5 %、4 0 0 % ,两组比较差异均有显著性 (P <0 0 1) ;治疗后治疗组患者血清HA、LN水平明显降低 ,肝脏活组织病理检查 (治疗组 8例 )证实肝纤维组织减少。实验研究结果证实血隆冲剂 9 6g/kg组大鼠肝组织中羟脯氨酸含量明显下降 ;光、电镜均能发现用药组大鼠肝组织中纤维组织增生减轻。结论 :血隆冲剂有抗肝纤维化作用。

Objective: To study the clinical effect and mechanism of Xuelong Granule (XLG) in antiliver fibrosis. Methods: Ninety eight patients with liver cirrhosis were divided into 2 groups randomly. The 58 Patients in the treated group were treated by XLG and the 40 patients in the control group were treated by Shenchai Granule for 3 months. Levels of serum hyaluronic acid (HA) and laminin (LN), and pathological changes of liver tissues were observed before and after treatment. In experimental study on model rats, the liver tissue content of hydroxyproline and pathological changes under light and electron microscope were observed. Results: The total effective rate in the treated group was 72.4%, that in the control group was 40.0%, there was significant difference between the two groups (P<0 01). The level of serum HA and LN in the treated group declined markedly after treatment, and pathological examination of 8 cases showed the fibrous tissues reduced obviously. Experimental study showed marked reduction of hydroxyproline content and significant lowering of fibrous tissue proliferation, both under light and electron microscope, in liver of model rats after XLG treatment. Conclusion: XLG has a definite effect in anti liver fibrosis.